Doctors often order tests and recommend drugs or procedures when they shouldn?t Doctors often order tests and recommend drugs or procedures when they shouldn?t ? sometimes even when they know they shouldn?t. The problem has become so serious that such groups as the American College of Physicians, the ABIM Foundation, the National Physicians Alliance and a coalition of medical societies in a project called Choosing Wisely have compiled lists of tests and treatments that doctors themselves say are done too often. Below are five top examples from those lists.
Source: Washington Post Posted on:
Tuesday, Jun 05, 2012, 8:49am Views: 53
ScienceDaily (June 4, 2012) ? New microscope enabled scientists at EMBL Heidelberg to film a fruit fly embryo, in 3D, from when it was about two-and-a-half hours old until it walked away from the microscope as a larva.
"This video shows a fruit fly embryo from when it was about two-and-a-half hours old until it walked away from the microscope as a larva, 20 hours later," says Lars Hufnagel, from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. "It shows all the hallmarks of fruit fly embryonic development in three dimensions."
The video was obtained using a new microscope created by Hufnagel's lab and described online recently in Nature Methods. In it, you can watch as cells on the embryo's belly dive in to form what's known as the ventral furrow. Other cells can then be seen moving around the embryo's rear end to its back (inset), in a process called convergent extension. And later, when an opening appears in the embryo's back (inset), see the surrounding cells close the gap in a process known as dorsal closure.
The new microscope, called Multi-View SPIM, or MuVi-SPIM for short, enables scientists to image rapid biological processes in thick samples at unprecedented detail. It builds upon the Selective-Plane Illumination Microscopy (SPIM) technology developed at EMBL a few years ago. Like SPIM, the new microscope shines a thin sheet of light on the embryo, illuminating one layer of a sample like this embryo at a time, to obtain an image of the whole sample with minimal light-induced damage. But MuVi-SPIM takes four full images from different angles, eliminating the need to rotate the sample. This speeds up the imaging and enables scientists to merge the four images into a single high-quality three-dimensional image for the first time.
Hufnagel and colleagues can obtain a high-quality three-dimensional image of a fruit fly embryo in a few seconds, and be ready to repeat the process. This means the different images that make up the video are taken in such rapid succession that very little has changed in the embryo from one frame to the next -- so scientists can be sure of where each cell -- or even structures inside cells -- is and track it throughout the video. Using such fast imaging, Hufnagel and colleagues were able to record the movements of every nucleus in the embryo not only during the later developmental stages shown here, but also throughout the first three hours of the embryo's life, when nuclei divide very rapidly.
"Everything in this microscope is optimised for speed and light-sensitivity," says Uros Krzic from Hufnagel's lab, who designed the microscope. "Not just the optics, mechanics and cameras, but also the software that controls the microscope and processes the data. We can finally get high-quality data in real time."
In the future, the scientists would like to use their new microscope to investigate the how organs and tissues form, not only in the fruit fly but also in other model organisms.
The video is also available on the EMBL YouTube Channel: http://youtu.be/MefTPoeVQ3w.
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The above story is reprinted from materials provided by European Molecular Biology Laboratory (EMBL), via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Uros Krzic, Stefan Gunther, Timothy E Saunders, Sebastian J Streichan, Lars Hufnagel. Multiview light-sheet microscope for rapid in toto imaging. Nature Methods, 2012; DOI: 10.1038/NMETH.2064
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
PHILADELPHIA (AP) - After waiting nine years to reach the majors, Elian Herrera is making a strong case to stay.
Herrera hit a tiebreaking RBI single off Jonathan Papelbon in the ninth inning to lift the Los Angeles Dodgers over the Philadelphia Phillies 4-3 on Monday night.
"I really love this game," said Herrera, who was finally called up to replace the injured Juan Uribe earlier this month. "I would have liked to have been here before, but that's how it works. I just want to be in the lineup. It doesn't matter where I play."
Herrera is hitting .308 in 19 games. He's started at third base, second base and now center field.
"It's a testament to him that he continued to work hard," Dodgers manager Don Mattingly said. "I'm happy for him. I didn't even know he could play outfield. When Matt (Kemp) went down, they said he could play center."
Placido Polanco hit a tying, two-run homer to help the Phillies rally from a 3-0 deficit against Clayton Kershaw, but it wasn't enough.
Dee Gordon ripped a triple to right-center to start the ninth against Papelbon (0-2). Herrera followed with a grounder through the shortstop hole to put major league-leading Los Angeles ahead to stay.
Papelbon is 15 for 15 in save opportunities, but hasn't fared as well in non-save situations.
He wasn't pleased with plate umpire D.J. Reyburn, who had a tough night. Reyburn tossed Dodgers bench coach Trey Hillman and Mattingly earlier in the game. Papelbon thought he struck out Gordon the pitch before allowing the triple. After the inning, he walked over to talk to Reyburn, who walked away.
"I just wanted to ask him if he could throw me out for what I was thinking," Papelbon said. "He was terrible all night. He probably needs to go back to Triple-A. If you don't do your job, you get demoted or fired. It affected the outcome of the game."
Kershaw, the reigning NL Cy Young Award winner, gave up three runs and eight hits in seven innings to remain winless in his last three starts.
Ronald Belisario (1-0) tossed a scoreless eighth and Kenley Jansen finished for his seventh save in 10 tries.
The five-time defending NL East champion Phillies have lost three straight to fall back to .500. But they're just four games behind first-place Washington.
Phillies starter Vance Worley allowed four runs and five hits in four innings in his first start since May 11. Worley had been sidelined with an elbow injury.
"I wasn't perfect," Worley said. "I was around the zone, but didn't get it over. It got better as I went on."
John Mayberry Jr. got Philadelphia's rally started in the third with a line-drive double off the top of the wall in left. Freddy Galvis singled to right to drive him in. Two outs later, Polanco hit a tying shot out to left. Polanco fell behind in the count 0-2 and worked it full before connecting for just his second homer of the season. Polanco had gone deep just once in his previous 261 at-bats, counting the postseason.
Phillies right fielder Hunter Pence saved at least one run when he made a sliding catch on Gordon's hard liner with two outs and two runners on in the fourth.
The Phillies missed a chance to take a lead in the fifth after Jimmy Rollins lined a triple to left-center with one out. Polanco then hit a grounder to drawn-in shortstop Gordon, who easily threw out Rollins trying to score.
Pence grounded out weakly to second to leave the bases loaded in the seventh.
The Dodgers jumped on Worley in the first, taking advantage of his control problems to score two runs. Worley walked Herrera and Andre Ethier with one out. Juan Rivera and Bobby Abreu followed with consecutive RBI singles.
Los Angeles tacked on a third run in the second. Adam Kennedy led off with a bloop double to left. He advanced to third on Kershaw's sacrifice and scored on Gordon's infield single.
"Our bench has been big," Kershaw said. "We have a lot of guys hurt and other guys have been picking it up every night."
NOTES: Chase Utley went 3 for 4 with a home run and double as the designated hitter in an extended spring training game Monday in Clearwater, Fla. The five-time All-Star second baseman hasn't played for the Phillies this season because of a chronic knee condition. "That's a good sign," manager Charlie Manuel said of Utley's hitting performance in his debut. ... The Dodgers sent OF/1B Scott Van Slyke to Triple-A Albuquerque to make room for Rivera, who was activated from the 15-day disabled list. Los Angeles also placed RHP Javy Guerra on the DL because of right knee inflammation. RHP Shawn Tolleson was called up from Double-A Chattanooga to take his spot. ... A crowd of 45,572 was the 248th straight sellout at Citizens Bank Park, counting postseason play. ... Cliff Lee (0-2, 3.00) seeks his first win of the season on Tuesday night. Chad Billingsley (2-4, 4.09) starts for Los Angeles.
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Dodgers get to Papelbon
Elian Herrera hit a tiebreaking RBI single off Jonathan Papelbon in the ninth inning to lift the Los Angeles Dodgers over the Philadelphia Phillies 4-3 on Monday night.
Contact: Vincent Staupe vstaupe@golinharris.com 415-318-4386 Kaiser Permanente
No urgent need to get vaccinated to prevent a second shingles episode
PASADENA, Calif., June 5, 2012 People who have had an episode of herpes zoster, also known as shingles, face a relatively low short-term risk of developing shingles, according to a Kaiser Permanente Southern California study published online in the Journal of Infectious Diseases. These findings suggest that among people with immune systems that have not been compromised, the risk of a second shingles episode is low.
Researchers reviewed electronic health records and monitored recurrence of shingles for more than 6,000 individuals. They found fewer than 30 cases of recurrent shingles in an average of two years of follow-up and little difference in the rate of recurrence between the vaccinated and unvaccinated population.
"This study's findings are important because we found that the risk of having a recurrent shingles episode is not as high as previous research indicates," said Hung-Fu Tseng, PhD, MPH, study lead author with the Kaiser Permanente Southern California Department of Research & Evaluation in Pasadena, Calif. "We now have empirical data that show the risk of recurrence is low among an elderly population who did not have compromised immune systems, regardless of their vaccination status."
More than 1 million people develop shingles every year in the United States. Shingles is a painful contagious rash caused by the dormant chickenpox virus which can reactivate and replicate, damaging the nerve system. The elderly are especially vulnerable because immunity against the virus that causes shingles declines with age.
When the Food and Drug Administration approved the shingles vaccine in 2006, the agency said that having an episode of shingles boosts immunity and suggested it was unlikely that people would experience a recurrence. It further stated that the effectiveness of the vaccine in preventing repeat episodes had not been proven in clinical trials because trials have not been conducted.
By contrast, the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices recommended the herpes zoster vaccine for people ages 60 and older, including those who reported a previous episode.
"While this latest study adds to the growing evidence base of emerging knowledge about the shingles vaccine, more research is needed. Our findings need to be replicated by studies with larger populations. Kaiser Permanente Southern California researchers will continue to follow this population of vaccinated people in order to determine the long term preventative efficacy," said Dr. Tseng.
Researchers studied electronic health records for 1,036 vaccinated and 5,180 unvaccinated Kaiser Permanente members aged 60 and older. The vaccinated population included members who received vaccines between 2007 and 2010. The zoster vaccine is not recommended for patients with immune systems that have been compromised as a result of cancer or other medical conditions, so they were excluded from this study.
Based on the clinically confirmed cases, researchers found the risk of the recurrence of shingles after a recent episode is fairly low regardless of vaccination status. Each year, on average, 19 persons per 10,000 in the vaccinated cohort experienced a recurrence of shingles. The rate was only slightly higher for the unvaccinated population, at approximately 24 persons per 10,000 per year.
This is the latest in a series of published Kaiser Permanente studies conducted to better understand vaccine effectiveness and safety. Among these studies were:
In 2011, Dr. Tseng was a lead researcher in a Vaccine Safety Datalink study published in the Journal of Internal Medicine that found the herpes zoster vaccine to be safe.
Also last year, Dr. Tseng published a study in the journal Vaccine that found that administering the pneumococcal and the herpes zoster vaccines at the same time is as beneficial as if they are administered separately.
On top of that study, Dr. Tseng published a study in 2011 in the Journal of the American Medical Association that found that the shingles vaccine is associated with a 55 percent reduced risk of developing the disease.
In 2010, another study by Dr. Tseng in JAMA found the pneumococcal pneumonia vaccination is not associated with a reduced risk of heart attacks or strokes in men.
Two Kaiser Permanente studies found that the combination vaccine for measles, mumps, rubella, and chickenpox is associated with double the risk of febrile seizures for 1- to 2-year-old children, compared to same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella vaccine for chickenpox.
Other Kaiser Permanente studies found that children of parents who refuse vaccines are nine times more likely to get chickenpox and 23 times more likely to get pertussis (commonly known as whooping cough), compared to fully immunized children.
Another study found that herpes zoster is very rare among children who have been vaccinated against chickenpox.
###
Other study authors include: Steven J. Jacobsen, MD, PhD, Margaret Chi, MPH, Stephen M. Marcy, MD, Lina S. Sy, MPH, and Ning Smith, PhD, from the Department of Research & Evaluation, Kaiser Permanente Southern California.
About the Kaiser Permanente Department of Research & Evaluation
The Department of Research & Evaluation (R & E) conducts high-quality, innovative research into disease etiology, prevention, treatment and care delivery. Investigators conduct epidemiology, health sciences, and behavioral research as well as clinical trials. Areas of interest include diabetes and obesity, cancer, HIV/AIDS, cardiovascular disease, aging and cognition, pregnancy outcomes, women's and children's health, quality and safety, and pharmacoepidemiology. Located in Pasadena, Calif., the department focuses on translating research to practice quickly to benefit the health and lives of Kaiser Permanente Southern California members and the general population. Visit www.kp.org/research.
About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve more than 9 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to: www.kp.org/newscenter.
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?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Vincent Staupe vstaupe@golinharris.com 415-318-4386 Kaiser Permanente
No urgent need to get vaccinated to prevent a second shingles episode
PASADENA, Calif., June 5, 2012 People who have had an episode of herpes zoster, also known as shingles, face a relatively low short-term risk of developing shingles, according to a Kaiser Permanente Southern California study published online in the Journal of Infectious Diseases. These findings suggest that among people with immune systems that have not been compromised, the risk of a second shingles episode is low.
Researchers reviewed electronic health records and monitored recurrence of shingles for more than 6,000 individuals. They found fewer than 30 cases of recurrent shingles in an average of two years of follow-up and little difference in the rate of recurrence between the vaccinated and unvaccinated population.
"This study's findings are important because we found that the risk of having a recurrent shingles episode is not as high as previous research indicates," said Hung-Fu Tseng, PhD, MPH, study lead author with the Kaiser Permanente Southern California Department of Research & Evaluation in Pasadena, Calif. "We now have empirical data that show the risk of recurrence is low among an elderly population who did not have compromised immune systems, regardless of their vaccination status."
More than 1 million people develop shingles every year in the United States. Shingles is a painful contagious rash caused by the dormant chickenpox virus which can reactivate and replicate, damaging the nerve system. The elderly are especially vulnerable because immunity against the virus that causes shingles declines with age.
When the Food and Drug Administration approved the shingles vaccine in 2006, the agency said that having an episode of shingles boosts immunity and suggested it was unlikely that people would experience a recurrence. It further stated that the effectiveness of the vaccine in preventing repeat episodes had not been proven in clinical trials because trials have not been conducted.
By contrast, the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices recommended the herpes zoster vaccine for people ages 60 and older, including those who reported a previous episode.
"While this latest study adds to the growing evidence base of emerging knowledge about the shingles vaccine, more research is needed. Our findings need to be replicated by studies with larger populations. Kaiser Permanente Southern California researchers will continue to follow this population of vaccinated people in order to determine the long term preventative efficacy," said Dr. Tseng.
Researchers studied electronic health records for 1,036 vaccinated and 5,180 unvaccinated Kaiser Permanente members aged 60 and older. The vaccinated population included members who received vaccines between 2007 and 2010. The zoster vaccine is not recommended for patients with immune systems that have been compromised as a result of cancer or other medical conditions, so they were excluded from this study.
Based on the clinically confirmed cases, researchers found the risk of the recurrence of shingles after a recent episode is fairly low regardless of vaccination status. Each year, on average, 19 persons per 10,000 in the vaccinated cohort experienced a recurrence of shingles. The rate was only slightly higher for the unvaccinated population, at approximately 24 persons per 10,000 per year.
This is the latest in a series of published Kaiser Permanente studies conducted to better understand vaccine effectiveness and safety. Among these studies were:
In 2011, Dr. Tseng was a lead researcher in a Vaccine Safety Datalink study published in the Journal of Internal Medicine that found the herpes zoster vaccine to be safe.
Also last year, Dr. Tseng published a study in the journal Vaccine that found that administering the pneumococcal and the herpes zoster vaccines at the same time is as beneficial as if they are administered separately.
On top of that study, Dr. Tseng published a study in 2011 in the Journal of the American Medical Association that found that the shingles vaccine is associated with a 55 percent reduced risk of developing the disease.
In 2010, another study by Dr. Tseng in JAMA found the pneumococcal pneumonia vaccination is not associated with a reduced risk of heart attacks or strokes in men.
Two Kaiser Permanente studies found that the combination vaccine for measles, mumps, rubella, and chickenpox is associated with double the risk of febrile seizures for 1- to 2-year-old children, compared to same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella vaccine for chickenpox.
Other Kaiser Permanente studies found that children of parents who refuse vaccines are nine times more likely to get chickenpox and 23 times more likely to get pertussis (commonly known as whooping cough), compared to fully immunized children.
Another study found that herpes zoster is very rare among children who have been vaccinated against chickenpox.
###
Other study authors include: Steven J. Jacobsen, MD, PhD, Margaret Chi, MPH, Stephen M. Marcy, MD, Lina S. Sy, MPH, and Ning Smith, PhD, from the Department of Research & Evaluation, Kaiser Permanente Southern California.
About the Kaiser Permanente Department of Research & Evaluation
The Department of Research & Evaluation (R & E) conducts high-quality, innovative research into disease etiology, prevention, treatment and care delivery. Investigators conduct epidemiology, health sciences, and behavioral research as well as clinical trials. Areas of interest include diabetes and obesity, cancer, HIV/AIDS, cardiovascular disease, aging and cognition, pregnancy outcomes, women's and children's health, quality and safety, and pharmacoepidemiology. Located in Pasadena, Calif., the department focuses on translating research to practice quickly to benefit the health and lives of Kaiser Permanente Southern California members and the general population. Visit www.kp.org/research.
About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve more than 9 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to: www.kp.org/newscenter.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Our Welo Contributing writer Mikki Sage and Ashley Walsh of Intentional Chocolate are teaming up to throw Chocolate parties. The Chocolate Invitational is their latest adventure, which encompasses a series of sweet events, all in the name of Chocolate.
The Chocolate Invitational series will start in Venice and make its way around town then head up to Ojai?
Chocolate tastings and truffles provided by Intentional Chocolate, wine pairings by Rendarrio Wines, tea ceremonies by Temple Tea, Music By Joplin MacColl, culinary bites, photographic series, art and more. Proceeds will go to Walk with Sally Foundation. ?Tickets go on sales?June 1st, $30 ?to purchase go to: http://thechocolateinvitational.eventbrite.com/
Be sure to LIKE their page on FB where you?ll find out on the event. Location will be announced day of the event.
Series 1, Venice. June 28th, 7pm-11pm. It?s limited capacity, party is sure to sell out quickly. ?For More info and future locations? visit their website and facebook page.
This is the story of a very special tree.? It was left standing when the rest of the space was cleared to build a house many years ago.? This tree would shelter the little house.? It witnessed many changes over the years as horse and wagon changed to cars.? There were births and deaths on the farm, until finally it was the great-great grandson of the original building of the home who lived there.? The tree still stood, strong and straight.? But then it was threatened as a new road was planned that would run right through it.? The grandson refused to let the tree be cut down, and wild animals join him to keep it from happening.? So the road plans must be changed and the tree continues to grow now by the large bend in the road.
There is something to be said about a picture book that decides to tell the story that feels right, the one that resounds in your bones, rather than the one that would happen in real life.? When I saw the bulldozers in the book, I braced myself for heartache, or for the story to turn into that of growing a new tree from an acorn that originated with this tree.? But instead McPhail told a story for tree lovers of all ages, who wish that there were bends in the big highways to keep huge old trees alive.?
McPhail?s writing is simple and straight-forward.? He tells the story with a great matter-of-fact tone that belies the wildlife appearing and the wonder of the tree standing.? His art is signature McPhail with its fine ink lines and watercolor softness.? It has both the clarity of the modern day and the softness of memories.
Get this into the hands of those who hug trees.? They are guaranteed to love it.? Appropriate for ages 3-5.
Reviewed from copy received from Henry Holt and Company.
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Public release date: 5-Jun-2012
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